• Founder and Clinical Director of Eyereum Eye Clinic
  • Associate Adjunct professor in the ophthalmology, Yonsei University College of Medicine
  • EVO Toric ICL Reference Doctor (STAAR Surgical)
  • ICL Expert Instructor (STAAR Surgical)
  • Korea-Japan ICL Forum Key Opinion Leader
  • SMILE Expert Doctor (ZEISS)
  • Holding Surgical Instrument Patents for ICL, LASEK, Cataract, and SMILE Procedures
  • Official member of The Korean Ophthalmological Society
EYEREUM Founder & Medical Director Dr. Jin Young Choi

Paper presentation

TitleJournal Info
Dynamic vaulting changes in V4c versus V4 posterior chamber phakic lenses under different lighting conditionsAm J Ophthalmol. 2014 Aug 18. pii: S0002-9394(14)00501-7. doi: 10.1016/j.ajo.2014.08.020
Two cases of uveal effusion syndromeThe Korean Ophthalmological Society, 2006 Mar 047(03): 489-493
Expression of neurotrophic factors in human primary pterygial tissue and selective TNF-alpha-induced stimulation of ciliary neurotrophic factor in pterygial fibroblasts.Experimental and toxicologic pathology 2008 Sep;60(6) 513-20. Epub 2008 Jun 26

AMERICAN JOURNAL OF OPHTHALMOLOGY

OCTOBER 2014 VOLUME 158

약시 치료에 성공한 굴절부동약시, 사시약시, 혼합약시의 임상분석

임현택, 허영, 김승현. 고려대학교 의과대학 안과학교실, 시과학교실 연구소.

논문정보

Exp Toxicol Pathol. 2008 Sep;60(6):513-20. Epub 2008 Jun 26. Expression of neurotrophic factors in human primary pterygial tissue and selective TNF-alpha-induced stimulation of ciliary neurotrophic factor in pterygial fibroblasts. Hong S, Choi JY, Lee HK, Seong GJ, Seo KY, Kim EK, Byeon SH. Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

Pterygium is a degenerative, fibrovascular and hyperplastic growth resulting from a proliferative tissue actively growing from altered limbal stem cells at the corneal-conjunctival junction. However, the pathogenesis of pterygium is still unclear. The aim of this study was to determine the expression of neurotrophic factors (nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and neurotrophin (NT)-3, NT-4/5) in pterygial tissue and to confirm whether tumor necrosis factor-alpha (TNF-alpha) modulates the expression of these neurotrophic factors in primary cultured pterygial fibroblasts. We looked for expression of these neurotrophic factors in surgically excised pterygia and normal donor limbal tissues by immunohistochemistry and in primary cultured pterygial and normal subconjunctival Tenon's fibroblasts by Western blot and reverse transcription-polymerase chain reaction (RT-PCR). Expression of CNTF and NT-4/5 is increased in pterygial tissues compared with normal tissue, and production of CNTF is stimulated in pterygial fibroblasts by TNF-alpha but not in normal fibroblasts. This selective stimulation of CNTF in pterygial fibroblasts suggests that CNTF may play a role in the pathogenesis of pterygium.

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